Austin Yang is the Faculty Director and serves as advisor in all technical
and scientific matters of the Core. He will also interview researchers with
specific needs such as post-translational modifications as it relates to experiment
design and or writing grant applications. Dr. Yang is Associate Professor of
Anatomy and Neurobiology at the University of Maryland Medical School. Dr. Yang
has most recently served as an Associate Professor of Pharmaceutical Sciences
at the University of Southern California (USC). He completed his doctorate and
post-doctorate degrees in Biological Sciences from the University of California,
Irvine. Currently his group studies the effects of protein oxidation and post-translational
modifications on the assembly of protein complexes and cell signaling during
the course of aging and Alzheimer’s disease. This research has obvious
ramifications to cancer and carcinogenesis. In addition to his research, Dr.
Yang spends a great deal of time advising Core personnel and researches in areas
such as experimental design and proper proteomics language in grant applications.
His expertise in mass spectrometry-based, quantitative post-translational modifications,
in particular phosphorylation and ubiquitination, is invaluable for researchers
interested in detection of these modifications.
Dr. Stefani Thomas is the Proteomics Facility manager and a Research Associate in the Department of Radiation Oncology. She is responsible for directing and consulting with the Proteomics Facility personnel to determine the workflow following sample intake and interpreting data generated from the LC-MS/MS analysis of customers’ samples. She is also the principal operator of our nanoflow liquid chromatography system and our LTQ-Orbitrap mass spectrometer that provides enhanced mass accuracy and resolution. Dr. Thomas completed her doctoral training in both Pharmaceutical Sciences and Biological Mass Spectrometry at the University of Southern California. She has extensive experience with various protein post-translational modifications and protein complex analysis by mass spectrometry.
Dr. Yunhu Wan is the core’s bioinformaticist. He provides support
in the area of protein identification, by training Core personnel and investigators,
and by running the software himself. He is very much involved in the cutting
edge of bioinformatics by writing programs that help localize the site of phosphorylation
in peptides, thereby improving the speed with which these results can be achieved.
Currently, Dr. Wan is also in the process of developing several new computational
tools for various quantitative proteomics projects within the cancer center.