Radiation Oncology Program

Physicians and Staff

William F. Regine, M.D.

William F. Regine, M.D.

Professor and Chair, Department of Radiation Oncology

Education and Degrees

BS: State University of New York, Albany, NY
MD: State University of New York Health Science Center, Syracuse, NY
Residency: Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA
Fellowship: Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA

Areas of Interest

Administrative Assistant

Yvette Green
Phone: (410) 328-2326
Fax: (410) 328-6911

Dr. Regine's Recent Publications

  1. Huhn JL, Regine WF, Valentino J, Kudrimoti M, Kenady D, Sloan D, Spring P, Mohiuddin M. Use of high dose spatially fractionated radiation (GRID) as an adjunct for the treatment of advanced neck disease in patients with head and neck carcinomas. TCRT 2006, accepted for publication.

  2. Garofalo MC, Nichols EM, Regine WF. Is Adjuvant Therapy for Resected Pancreatic Cancer Needed? If Yes, Should it be Chemotherapy or Chemoradiation? GCR 2006, in press.

  3. D’Souza W, Nazareth D, Zhang B, Deyoung C, Suntharalingam M, Kwok Y, Yu CX, Regine W. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy. Medical Dosim 2006, in press.

  4. Patel S, Garofalo MC, Regine WF. Role of Radiotherapy in Treatment of Pancreatic Cancer. (Chapter 81) In: Beger H, Buchler M, Kozarek R, eds. The Pancreas, 2nd Edition Blackwell Publishing, Ltd, 2006, in press.

  5. Garofalo MC, Regine WF, Tan MT. On statistical reanalysis, the EORTC trial was a positive trial for adjuvant chemoradiation in pancreatic cancer. Ann Surg 2006 Aug;244(2):332-333.

  6. Kwok Y, DeYoung C, Garofalo MC, Dhople A, Regine W. Radiation Oncology Emergencies. Hematol Oncol Clin North Am 2006 Apr;20(2):505-22.

  7. Garofalo MC, Flannery T, Regine W. The Case for Adjuvant Chemoradiation in Pancreatic Cancer. Best Clinical Practice & Research: Clinical Gastroenterology 2006 Apr;20(2):403-416.

  8. Ha Jonathan, Zhang G, Naqvi SA, Regine WF, Yu CX. Feasibility of delivering GRID therapy using a multileaf collimator: Med Phys 2006;33(1):76-82.

  9. Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and gamma knife radiosurgery for trigeminal neuralgia treatments. Phys Med Biol 2005;(50):5217-5227.

  10. Ma L, Kwok Y, Regine WF. Concomitant GRID boost for gamma knife radiosurgery. Med Phys 2005;32(11):3419-3423.

  11. Spring P, Valentino J, Arnold S, Sloan D, Kenady D, Kudrimoti M, Haydon RC, Lee C, Mohiuddin M, Regine WF. Long-term results of hyperfractionated radiation and high-dose intra-arterial cisplatin for unresectable oropharyngeal carcinoma. Cancer 2005;104(8):1765-1771.

  12. Kwok Y, Regine W, Dibiase SJ. In reply to Dr. Rogers et al. Int J Radiat Oncol Biol Phys 2005 Jun 1;62(2):618-9.

  13. Gaugler J, Hanna N, Linder J, Given CW, Tolbert V, Kataria R, Regine WF. Cancer caregiving and subjective stress: A multi-site multi-dimensional analysis. Psycho-Oncology 2005;14:771-785.

  14. Patchell R, Tibbs P, Regine WF, Payne R, Saris S, Kryscio R, Mohiuddin M, Young B. A randomized trial of direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer. Lancet 2005;366:643-648.

  15. Garofalo M, Malloy P, Amin P, Jaboin J, Gutt R, Van Echo D, Regine W. Treatment of unresectable chemorefractory liver metastases with selective intrahepatic application of yttrium-90 microspheres (SIR-Spheres): Early U.S. experience. Int J Radiat Oncol Biol Phys 2005 63(2);Suppl 1:S161.

  16. Regine WF, Hanna N, Garofalo MC, Doyle A, Arnold S, Kataria R, Simms J, Mohiuddin. Radiation therapy (RT) as a chemosensitizer of gemcitabine (G) in patients with metastatic/unresectable tumors of the gastrointestinal (GI) tract - a phase I/II study exploring a new treatment paradigm. Int J Radiat Oncol Biol Phys 2005 63(2);Suppl 1:S13-14.

  17. Kwok Y, Garofalo M, Regine W. Postoperative Adjuvant Therapy for Pancreatic Cancer. (Chapter 27) In: Von Hoff DD, Evans DB, Hruban RH, eds. Pancreatic Cancer Jones and Bartlett Publishers, 2005 (ISBN 0-7637-2178-6).

  18. Kwok Y, Regine WF, Patchell RA. Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo. J Clin Oncol 2005 May 20;23(15):3308-10.

  19. DiBiase SJ, Kwok Y, Yovino S, Arena C, Naqvi S, Temple R, Regine WF, Amin P, Guo C, Chin LS. Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. Int J Radiat Oncol Biol Phys 2004;60(5):1515-1519.

  20. Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ, Hahn SM. A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Clin Cancer Res, 2004;10:547-54.

  21. Regine WF, Rogozinska A, Kryscio RJ, Tibbs PA, Young AB, Patchell RA. Recursive partitioning analysis classifications I and II: Applicability evaluated in a randomized trial for resected single brain metastases. Am J Clin Onc 2004;27(5):505-509.

  22. Cheuk AV, Chin LS, Petit JH, Herman JM, Fang HB, Regine WF. Imaging correlates of gamma knife outcome in trigeminal neuraliga. Int J Radiat Oncol Biol Phys 2004;60 (2):537-541.

  23. Regine WF, Schmitt FA, Scott CB, Dearth C, Patchell RA, Nichols, RC, Gore EM, Franklin RL, Suh JH, Mehta MP. Feasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: Results of Radiation Therapy Oncology Group Trial BR-0018. Int J Radiat Oncol Biol Phys 2004;58(5):1346-1352.

  24. Shehata MK, Young AB, Reid B, Patchell RA, St Clair W, Sims J, Sanders M, Meigooni AS, Mohiuddin M, Regine WF. Stereotatic radiosurgery (SRS) of 468 brain metastases = 2 cm: implications for SRS dose and whole brain radiation therapy (WBRT). Int J Radiat Oncol Biol Phys 2004;59(1):87-93.

  25. Flannery TW, Suntharalingam M, Kwow Y, Koffman BH, Amin PP, Chin LS, Nicol B, Fowler, Young AB, Regine WF. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer 2003;42:327-333.

  26. Arnold SM, Regine WF, Ahmed MM, Valentino J, Spring P, Kudrimoti M, Kenady D, Desimone P, Mohiuddin M. Low-dose fractionated radiation as a chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally advanced squamous cell carcinoma of the head and neck: Results of a new treatment paradigm. Int J Radiat Oncol Biol Phys 2004;58(5):1411-1417.

  27. Garofalo MC, Kwok Y, Regine WR. The evolving role of postoperative adjuvant radiation therapy for pancreatic cancer. Surg Oncol Clin N Am 2004 Oct;13(4):589-604.

  28. Flannery TW, Suntharalingam M, Kwow Y, Koffman BH, Amin PP, Chin LS, Nicol B, Fowler, Young AB, Regine WF. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer 2003;42:327-333.

  29. Chin LS, Szerlip NJ, Regine WF. Stereotactic Radiosurgery for meningiomas. Neurosurg Focus 2003;14(5):1-6.

  30. Patchell RA, Regine WF. The rationale for adjuvant whole brain radiation therapy with radiosurgery in the treatment of single brain metastases. Tech Ca Res Treat 2003; 2(2):111-115.

  31. Anderson T, Regine WF, Kryscio R, Patchell RA. Neurologic complications of bladder cancer. A review of 359 cases. Cancer 2003;97:2267-72.

  32. Dey S, Spring PM, Arnold S, Valentino J, Chendil D, Regine WF, Mohiuddin M, Ahmed MM. Low-dose fractionated radiation potentiates the effects of paclitaxel in wild-type and mutant p53 head and neck tumor cell lines. Clin Ca Res 2003 Apr;9:1557-1565.

  33. Patchell RA, Regine WF, Ashton P, Tibbs PA, Wilson D, Shappley D, Young BY. A phase I trial of continuously infused intratumoral bleomycin for the treatment of recurrent glioblastoma multiforme. J Neuro-Onc 2002;60:37-42.

  34. Mohiuddin M, Damodaran C, Swatee D, Alcock R, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 status on radiation and 5-flourouracil synergy in pancreatic cancer cells. Anticancer Res 2002;22:825-830.

  35. Mohiuddin M, Kudrimoti M, Regine WF, McGrath P, Hanna N, Meeker T, John W. Concurrent infusional gemcitabine and radiation in the treament of advanced unresectable gi malignancy: A phase I study. Cancer Journal 2002;8:255-262.

  36. Hahn SM, Bernard EJ, Regine WF, Mohiuddin M, Haller DG, Stevenson JP, Smith D, Pramanik, B, Tepper J, Delaney TF, Kiel KD, Morrison B, Deutsch P, Muschel RJ, McKenna WG. A Phase I trial of the farnesyltransferase inhibitor l-778,123 and radiotherapy for locally advanced lung and head and neck cancer. Clin Cancer Res 2002;8:1065-1072.

  37. Valentino J, Spring PM, Shane M, Arnold SM, Regine WF. Interval pathologic assessments in patients treated with concurrent hyperfractionated radiation and intraarterial cisplatin (hyperradplat). Head and Neck 2002;24:539-544.

  38. Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto PW, Mehta MP. A Multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain raditherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 2002;53(3):519-526.

  39. Mohiuddin M, Chendil D, Dey S, Alcock RA, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 status on radiation and 5-flourouracil synergy in pancreatic cancer cells. Anticancer Res 2002;22:825-830.

  40. Sathishkumar S, Dey S, Meigooni AS, Regine WF, Kudrimoti M, Ahmed MM, Mohiuddin M. The impact of TNF-induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation. Technol Cancer Res Treat 2002;1:141-147.

  41. Regine WF, Valentino J, Arnold SM, Sloan D, Kenady D, Strottmann J, Mohiuddin M. A Phase II study of concomitant hyperfracionated radiation therapy and double dose intra-arterial cisplatin for squamous cell carcinoma of the head and neck. Technol Cancer Res Treat 2002;1:133-140.

  42. Regine WF, Reid B, Patchell RA, St.Clair WH, Meigooni AS, Sims J, Sanders M, Young AB. Efficacy of 20 Gy stereotactic radiosurgery for < 2 cm brain metastases. Radiosurgery 2002;4:134-142.

  43. Meigooni AS, Parker SA, Zheng J, Kalbaugh KJ, Regine WF, Mohiuddin M. Dosimetric characteristics with spatial fractionation using electron GRID therapy. Med Dosim 2002;27(1):37-42.

  44. Regine WF, Huhn JL, Patchell RA, St. Clair WH, Strottmann J, Meigooni AS, Sanders M, Young AB. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: Results and implications. Int J Radiat Oncol Biol Phys 2002;52(2):333-338.

  45. Jackson TR, Regine WF, Wilson D, Davis DG. Cerebellar liponeurocytoma: Case report, review of the literature and therapeutic implications. J Neurosurg 2001;95(S4): 700-703.

  46. Regine WF, Scott C, Murray K, Curran W. Neurocognitive outcome in brain metastasis patients treated with accelerated fractionation vs. accelerated hyperfractionated radiotherapy: An analysis from Radiation Therapy Oncology Group Study 91-04. Int J Radiat Oncol Biol Phys 2001;51(3):711-717.

  47. Sanghavi SN, Miranpuri SS, Chappell R, Buatti JM, Sneed PK, Suh JH, Regine WF, Weltman E, King VJ, Goetsch SJ, Breneman JC, Sperduto PW, Scott C, Mabanta S, Mehta MP. Radiosurgery for patients with brain metastases: A Multi-institutional analysis, stratified by the rtog recursive partitioning analysis methodology. Int J Radiat Oncol Biol Phys 2001;51(2):426-434.

  48. Regine WF, Valentino J, Arnold SM, Haydon RC, Sloan D, Kenady D, Strottman J, Pulmano C, Mohiuddin M. High-dose intra-arterial cisplatin boost with hyperfractionated radiation therapy for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 2001;19(14):3333-3339.

  49. Regine WF, Patchell RA, Strottman J, Meigooni AS, Sanders M, Young BA. Combined stereotactic split-course fractionated gamma knife radiosurgery and conventional radiation therapy for unfavorable gliomas: A phase I study. J Neurosurg 200;93(S3): 37-41.

  50. Nicol B, Regine WF, Courtney C, Meigooni AS, Sanders M, Young B. Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia. J Neurosurg 200;93(S3):152-154.

  51. Gamburg ES, Regine WF, Patchell RA, Strottmann JM, Mohiuddin M, Young AB. The prognostic significance of midline shift on survival of patients presenting with glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2000;48(5):1359-1362.

  52. Mohiuddin M, Hayne M, Regine WF, Hanna N, Hagihara P, McGrath P, Marks GM. Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. Int J Radiat Oncol Biol Phys 2000;48(4):1075-1080.

  53. Regine WF, Valentino J, John J, Storey G, Sloan D, Kenady D, Patel P, Pulmano C, Arnold S, Mohiuddin M. High-dose intra-arterial cisplatin and concurrent hyperfractionated radiation therapy in patients with locally advanced squamous cell carcinoma of the head and neck: Report of a phase II study. Head & Neck 2000;22: 543-549.

  54. Regine WF, Patchell RA, Strottman J, Sanders M, Meigooni AS, Young AB. Preliminary report of a phase i study of combined fractionated stereotactic radiosurgery and conventional external beam radiation therapy for unfavorable gliomas. Int J Radiat Oncol Biol Phys 2000;48(2):421-426.

  55. Regine WF, John WJ, McGrath P, Strodel WE, Mohiuddin M. The feasibility of dose escalation using concurrent radiation and 5-Fluorouracil therapy following pancreaticoduodenectomy for pancreatic carcinoma. J of Hepatobiliary Pancreat Surg 2000;7:53-57.

  56. Mohiuddin M, Regine WF, John WJ, Hagihara PF, McGrath PC, Kenady DE, Marks G. Preoperative chemoradiation in fixed distal rectal dancer: Dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys 2000;46(4):883-888.

  57. Valentino J, Weinstein L, Rosenblum R, Regine WF, Weinstein M. Radiation and intra-arterial cisplatin. Effects on arteries and free tissue transfer. Arch Otolaryngol Head Neck Surg 2000;126:215-219.

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