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Home >Information for Patients > Dictionary Index

Dictionary of Cancer Terms

Frameshift mutation
An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence. Such mutations usually lead to the creation of a premature termination (stop) codon, and result in a truncated (shorter-than-normal) protein product.



 
 
Source: National Cancer Institute Dictionary of Cancer Terms, available at www.cancer.gov/dictionary.