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Dictionary of Cancer Terms

View in Spanish: Inhibidor PARP-1 ABT-888

PARP-1 inhibitor ABT-888 (… in-HIH-bih-ter…)
A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. PARP-1 inhibitor ABT-888 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor. Also called ABT-888.



 
 
Source: National Cancer Institute Dictionary of Cancer Terms, available at www.cancer.gov/dictionary.