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Maintaining healthy skin may relieve pruritus. Good skin care includes adequate nutrition and daily fluid intake, protection from the environment, and cleansing practices that don't dry the skin.

Some specific factors that may relieve itching are the following:

In addition to the skin-care factors, medications applied to the skin or taken by mouth may be necessary to treat pruritus. Antibiotics may relieve itching caused by infection. Antihistamines may be useful in some cases of pruritus. Sedatives, tranquilizers, and antidepressants may be useful treatments. Aspirin seems to have reduced itching in some patients but increases it for others. Aspirin combined with cimetidine may be effective for patients with Hodgkin lymphoma or polycythemia vera.

Interrupting the itch-scratch-itch cycle, an increase in itching that can result from the process of scratching, may also help to alleviate pruritus. The cycle may be broken by applying a cool washcloth or ice over the affected area. Rubbing the skin and applying pressure or vibration to the skin may also help. Other methods that may be useful in relieving symptoms include distraction, music therapy, relaxation, and imagery techniques.