Langerhans cell histiocytosis (LCH) in adults is a lot like LCH in children and can form in the same organs and systems as it does in children. These include the endocrine and central nervous systems, liver, spleen, bone marrow, and gastrointestinal tract. In adults, LCH is most commonly found in the lung as single-system disease. LCH in the lung occurs more often in young adults who smoke. Adult LCH is also commonly found in bone or skin.
As in children, the signs and symptoms of LCH depend on where it is found in the body. See the
Tests that examine the organs and body systems where LCH may occur are used to detect (find) and diagnose LCH. See the
In adults, there is not a lot of information about what treatment works best. Sometimes, information comes only from reports of the diagnosis, treatment, and follow-up of one adult or a small group of adults who were given the same type of treatment.
Sometimes LCH of the lung will go away or not get worse even if it's not treated.
Treatment for LCH that affects only the bone in adults may include:
Treatment for LCH that affects only the skin in adults may include:
Treatment for LCH that affects the skin and other body systems may include:
Treatment of single-system and multisystem disease in adults may include:
For more information about LCH trials for adults, see the
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with