A Part of the University of Maryland Medical Center

• General Information About Childhood Non-Hodgkin Lymphoma
• Stages of Childhood Non-Hodgkin Lymphoma
• Recurrent Childhood Non-Hodgkin Lymphoma
• Treatment Option Overview
• Treatment Options for Childhood Non-Hodgkin Lymphoma
• To Learn More About Childhood Non-Hodgkin Lymphoma

• Hematologic Malignancies Program

• Diagnosis and Treatment...
• Physicians and Staff
• Q&A with Dr. Maria Baer
• Patient Education...
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    Related Resources
• Clinical Trials
• Information for Patients

Treatment Options for Childhood Non-Hodgkin Lymphoma

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Low-stage Childhood Non-Hodgkin Lymphoma

Treatment of low-stage (stage I or II) non-Hodgkin lymphoma in children and adolescents may include the following:

• Surgery followed by combination chemotherapy.
• Surgery and/or radiation therapy for anaplastic large cell lymphoma that affects the skin.
• A clinical trial of a new treatment.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I childhood large cell lymphoma, stage I childhood small noncleaved cell lymphoma, stage I childhood lymphoblastic lymphoma, stage I childhood anaplastic large cell lymphoma, stage II childhood large cell lymphoma, stage II childhood small noncleaved cell lymphoma, stage II childhood lymphoblastic lymphoma and stage II childhood anaplastic large cell lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

High-stage Childhood B-cell Non-Hodgkin Lymphoma

Treatment for high-stage (stage III or IV) B-cell (Burkitt and Burkitt-like) non-Hodgkin lymphoma in children and adolescents may include the following:

• Combination chemotherapy.
• Intrathecal or systemic chemotherapy for cancer in the brain or spinal cord.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III childhood large cell lymphoma, stage III childhood small noncleaved cell lymphoma, stage IV childhood large cell lymphoma and stage IV childhood small noncleaved cell lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

High-stage Childhood Lymphoblastic Lymphoma

Treatment of high-stage (stage III or IV) lymphoblastic lymphoma in children and adolescents may include the following:

• Combination chemotherapy with or without radiation therapy to the brain.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III childhood lymphoblastic lymphoma and stage IV childhood lymphoblastic lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

High-stage Childhood Anaplastic Large-cell Lymphoma

Treatment of high-stage (stage III or IV) anaplastic large-cell lymphoma in children and adolescents may include the following:

• Combination chemotherapy.
• Intrathecal or systemic chemotherapy for cancer in the brain or spinal cord.
• A clinical trial of new combination chemotherapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III childhood anaplastic large cell lymphoma and stage IV childhood anaplastic large cell lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Recurrent Childhood Non-Hodgkin Lymphoma

There is no standard treatment for patients with recurrent childhood non-Hodgkin lymphoma.

All patients with recurrent childhood non-Hodgkin lymphoma should be considered for clinical trials of new treatments.

Burkitt lymphoma and diffuse large B-cell lymphoma

Treatment options for recurrent Burkitt lymphoma and diffuse large B-cell lymphoma include:

• Combination chemotherapy.
• Combination chemotherapy and targeted therapy with a monoclonal antibody.
• High-dose chemotherapy with stem cell transplant.

Lymphoblastic lymphoma

Treatment options for recurrent lymphoblastic lymphoma include:

• Combination chemotherapy.
• High-dose chemotherapy with stem cell transplant.

Anaplastic large-cell lymphoma

Treatment options for recurrent anaplastic large cell lymphoma include:

• Chemotherapy with one or more drugs.
• High-dose chemotherapy with stem cell transplant.
• A clinical trial of targeted therapy with a tyrosine kinase inhibitor.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent childhood non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Lymphoproliferative Disease Associated with a Weakened Immune System

Treatment of lymphoproliferative disease in children and adolescents with weakened immune systems may include the following:

• Surgery with or without radiation therapy.
• Combination chemotherapy.
• Low-dose chemotherapy.
• A clinical trial of stem cell transplant followed by donor lymphocyte infusion or an infusion of T-cell lymphocytes that have been treated in the laboratory.