Childhood Ependymoma Treatment
General Information About Childhood Ependymoma
Key Points for this Section
Childhood ependymoma is a disease in which malignant (cancer)
cells form in the tissues of the brain and spinal cord.
The brain controls vital functions such as memory and learning, the
senses (hearing, sight, smell, taste, and touch), and emotion. The spinal cord
is made up of bundles of nerve fibers that connect the brain with nerves in
most parts of the body.
About 1 in 11 childhood brain
ependymomas. Although cancer is rare
in children, brain tumors are the most common type of childhood
cancer other than
This summary refers to the treatment of primary brain tumors (tumors that begin in the
brain). Treatment of metastatic
brain tumors, which are
tumors formed by cancer cells that
begin in other parts of the body and spread to the brain, is not discussed in
There are many different types of brain tumors. Brain tumors can occur in both children and adults; however,
treatment for children may be different than treatment for adults. See the following PDQ summaries for more information:
The central nervous system controls many important body functions.
Ependymomas most commonly form in these parts of the central nervous system (CNS):
- Cerebrum: The largest part of the brain, at the top of the head. The cerebrum controls thinking, learning, problem-solving, speech, emotions, reading, writing, and voluntary movement.
- Cerebellum: The lower, back part of the brain (near the middle of the back of the head). The cerebellum controls movement, balance, and posture.
- Brain stem: The part that connects the brain to the spinal cord, in the lowest part of the brain (just above the back of the neck). The brain stem controls breathing, heart rate, and the nerves and muscles used in seeing, hearing, walking, talking, and eating.
- Spinal cord: The column of nerve tissue that runs from the brain stem down the center of the back. It is covered by three thin layers of tissue called membranes. The spinal cord and membranes are surrounded by the vertebrae (back bones). Spinal cord nerves carry messages between the brain and the rest of the body, such as a signal from the brain to cause muscles to move or from the skin to the brain for the sense of touch.
Anatomy of the brain, showing the cerebrum, cerebellum, brain stem, and other parts of the brain.
Anatomy of the inside of the brain, showing the pineal and pituitary glands, optic nerve, ventricles (with cerebrospinal fluid shown in blue), and other parts of the brain.
The cause of most childhood brain tumors is unknown.
The symptoms of childhood ependymoma vary and often depend on
the child’s age and where the tumor is located.
The following symptoms and others may be
caused by childhood ependymoma. Other conditions may cause the same symptoms. A doctor should be
consulted if any of these problems occur:
Tests that examine the brain and spinal cord are used to detect
(find) childhood ependymoma.
The following tests and procedures may be used:
- Physical exam and history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.
- Neurological exam: A series of questions and tests to check the brain, spinal cord, and nerve function. The exam checks a person’s mental status, coordination, and ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam or a neurologic exam.
- CT scan (CAT
scan): A procedure that makes a series of detailed pictures of areas inside the
body, taken from different angles. The pictures are made by a computer
linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This
procedure is also called computed tomography, computerized tomography, or
computerized axial tomography.
- MRI (magnetic
resonance imaging) with gadolinium: A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the brain and spinal cord. A substance called gadolinium is injected into the patient through a vein. The gadolinium collects around the cancer cells so they show up brighter in the picture. This procedure is also called nuclear magnetic resonance imaging (NMRI).
- Lumbar puncture: A procedure used to collect cerebrospinal fluid from the spinal column to check for cancer cells. This is done by placing a needle into the spinal column. This procedure is also called an LP or spinal tap.
Childhood ependymoma is diagnosed and removed in surgery.
If a brain tumor is suspected, a biopsy is done by removing part of the skull and using a needle to remove a sample of the brain tissue. A pathologist views the tissue under a microscope to look for cancer cells. If cancer cells are found, the doctor will remove as much tumor as safely possible during the same surgery. An MRI may be done after the tumor is removed to find out how much tumor remains.
Certain factors affect prognosis (chance of
recovery) and treatment options.
The prognosis (chance of recovery) and treatment options depend on:
- Whether cancer cells remain after surgery.
- The type of ependymoma and whether it begins in the brain or in the spinal cord.
- The age of the child when the tumor is diagnosed.
- Whether the cancer has spread to other parts of the central nervous system, such as the meninges (membranes covering the brain) and the spinal cord.
- Whether the cancer has spread to other parts of the body, such as the bone or lung.
- Whether the tumor has just been diagnosed or has recurred (come back).